Innovative Research
We have proven experience in implementing research programs in oncology and pharmacology. Our projects include evaluating the anticancer activity of metal-based compounds and SSAO inhibitors, as well as analyzing the molecular signaling pathways involved in their mechanisms of action.
We place particular emphasis on developing targeted delivery systems and integrating remote monitoring technologies to enhance the precision and clinical relevance of the data obtained. All studies are conducted in collaboration with physician-researchers and take place at their clinical facilities, in full compliance with rigorous scientific and ethical standards.
Food Science & Nutraceuticals
Edible Dual-Action Matrix for Drug Delivery via Oral Mucosa and Stomach
A novel edible matrix was developed to enable dual-phase drug delivery: initial absorption through the oral mucosa followed by release in the stomach. The matrix activates salivation during chewing, allowing medications to be taken without water.
Unexpectedly, certain matrix types demonstrated strong potential for use in the food industry. Their modifiable texture and functional properties support the creation of a new category of food products — functional snacks with prolonged chewing time, controlled consistency transformation, and customizable nutritional profiles.
https://www.globaltrials.eu/applied-matrix-technology-for-sustainable-food-processing/
PATENTS
DE DE20314733U1 Kacugin, Leo, Dr.med.
Priority 2003-09-24 • Filed 2003-09-24 • Published 2004-03-04
The tablets with a low water content for mouth hygiene consist of commercially available tooth pastes.
EP DE EP3895672A1 Leo Kacugin
Priority 2020-04-14 • Filed 2021-02-19 • Published 2021-10-20
The present invention relates to a device for protecting the eyes from biologically hazardous microparticles made of transparent, flexible, electrostatically activated film which, after rubbing with the hands, covers the face and adheres to the skin without fastening elements.
DE DE202025003096U1 Leo Kacugin
Priority 2025-10-15 • Filed 2025-10-15 • Published 2025-11-21
A universally modifiable chewing matrix with a basic structure of natural whole grain components of plant origin, in particular from gluten-containing cereals such as wheat (Triticum aestivum) and spelt (Triticum spelta), characterized in that the matrix has a protein-polysaccharide network …
DE DE202025002817U1 Leo Kacugin
Priority 2025-09-23 • Filed 2025-09-23 • Published 2025-10-28
Plant-based chewing matrix comprising an elastically deformable, cohesive structure based on hydrated whole grain, in particular whole grain spelt (Triticum spelta), characterized by a stable phase with a defined chewing duration and sensory stability under conditions of body temperature (approx.
DE DE202025002859U1 Leo Kacugin
Priority 2025-09-26 • Filed 2025-09-26 • Published 2025-10-18
Plant-based chewing matrix, in particular in the form of strips, pellets, slabs, bars, multi-layered structures or dimensionally stable dosing units, characterized in that it is made from fully hydrated whole grain with a water content of at least 25%, wherein the matrix forms an elastically …
DE DE202025002287U1 Leo Kacugin
Priority 2025-08-09 • Filed 2025-08-09 • Published 2025-10-08
Chewing mass comprising a homogenized plant matrix consisting of cereals that are either pre-germinated or non-germinated but softened by water absorption, or a combination of pre-germinated and non-germinated, softened cereals, wherein the cereals may be of one or more different species.
DE DE202015003300U1 Leo Kacugin
Priority 2015-05-05 • Filed 2015-05-05 • Published 2015-08-07
A dentifrice for natural teeth cleaning and halitosis, characterized by containing clinoptilolite powder, xylitol, microcrystalline cellulose powder, sodium bicarbonate and natural flavor.
DE DE102020002265A1 Leo Kacugin
Priority 2020-04-11 • Filed 2020-04-11 • Published 2021-10-14
Disposable device to protect the eyes from biohazardous microparticles made of transparent, flexible, electrostatically activated film which, after rubbing with the hands, covers the face, adheres to the skin without fasteners and the penetration of microparticles into the eyes as a result of both …
DE DE202025003966U1 Leo Kacugin
Priority 2025-12-18 • Filed 2025-12-18 • Published 2026-01-27
An edible, chewable dosage form with a coherent, structurally stable matrix body, characterized in that the matrix body is formed from plant-based base components which, as a result of targeted processing, form a dense, elastic network structure, wherein the matrix body exhibits a two-phase …
DE DE202025002012U1 Leo Kacugin
Priority 2025-07-21 • Filed 2025-07-21 • Published 2025-08-28
Gum base comprising fermented cereal components, wherein the cereal components are selected from at least one cereal type from the group consisting of oats, wheat, rye, barley and sorghum, characterized in that the fermented cereal components have a modified molecular structure through water- …
Patent applications filed in the United States
1. Edible Chewing Mass Based on Fermented Cereal Grains
2. Method for Producing a Multifunctional Chewable Edible Matrix from Biologically Transformed Plant-Based Raw Materials
